LATIN DICTIONARYLexicon Latīnum
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“commerce” in Latin

The English word commerce itself goes back to Latin merx, through commercium.

Riddle & Arnold A Copious and Critical English–Latin Lexicon, 1864

commerce
mercatura (especially of the merchant): mercatio (commercial transaction, the buying and selling, Gell., 3, 3): negotium, or plur., negotia (the business which anybody carries on, especially as corn-merchant and money-lender): commercium (commerce, commercial intercourse, Sall., Jug: 18, 6: Pliny 33, 1, 3; with anything, alicujus rei, Plin., 12, 14, 30: then also = liberty of commerce): wholesale business, mercatura magna et copiosa: in retail, mercatura tenuis [Vid: TRADE]. The Roman merchants carry on a commerce with Gaul, mercatores Romani ad Gallos commeant (i. e., they visit Gaul with their merchandise, Caes., B.G., 1, 1).
Social intercourse, conversatio (Velleius, Quint..): usus: consuetudo (of his service, etc.): convictus (in so far as one lives with anybody): Vid: INTERCOURSE.
commerce v.
Vid: the above article.

Quick answer

What is the Latin word for commerce?
The usual Latin words for “commerce” are mercor, mercātiō, negōtium; also commercium, conversātiō, ūtor. The right choice depends on the sense; see the distinctions below.

Entry from J. E. Riddle & T. K. Arnold, A Copious and Critical English–Latin Lexicon (rev. C. Anthon, New York: Harper, 1864), digitised by Fergus J. P. Walsh, CC BY-SA 4.0; Latin markup adapted by latindictionary.co.