LATIN DICTIONARYLexicon Latīnum
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“depopulate” in Latin

The English word depopulate itself goes back to Latin populor, through dēpopulātus.

Riddle & Arnold A Copious and Critical English–Latin Lexicon, 1864

depopulate
To depopulate a country, terram vacuefacere; incolas terra ejicere (to remove the inhabitants; Vid: Nep., Cim., 2, 5): vastare; devastare; pervastare (to lay waste; make uninhabitable for men; devastare and pervastare, to make so utterly): populari; depopulari; perpopulari (to lay waste by an army, so as to drive away the inhabitants, and destroy whatever can afford them subsistence, especially by robbery and plunder): to depopulate and lay waste by fire and sword, ferro ignique, or igni ferroque vastare; ferro flammisque pervastare.

Quick answer

What is the Latin word for depopulate?
The usual Latin words for “depopulate” are vāstō, dēvāstō, populāris; also dēpopulor. The right choice depends on the sense; see the distinctions below.

Entry from J. E. Riddle & T. K. Arnold, A Copious and Critical English–Latin Lexicon (rev. C. Anthon, New York: Harper, 1864), digitised by Fergus J. P. Walsh, CC BY-SA 4.0; Latin markup adapted by latindictionary.co.